A Preliminary Report on a Modified Friedman Pregnancy Test.
نویسنده
چکیده
The Friedman (1939) test for pregnancy has the minor disadvantages that skill is required for the intravenous injection into the ear vein of the rabbit and that some 3 % (Albert, 1949; Evans and Krajian, 1944) of urine samples are toxic to the rabbit if injected intravenously. Ducey (1950) overcame some of these difficulties by injecting urine subcutaneously in doses of 20 to 30 ml. in the loose skin between the scapulae. Using this subcutaneous technique the large, subcutaneous bulge of injected urine, and the not inconsiderable amount of squirming of the test animal while the urine was being injected, were striking disadvantages. Toxic manifestations were not unknown with the subcutaneous technique, especially if the urine was old and somewhat contaminated. Friedman and Lapham (1931) found that by doubling the minimum effective dose they could produce strongly positive results, i.e., more than six corpora haemorrhagica in both ovaries. Ducey (1950) found, too, that the minimum effective dose by subcutaneous injection was twice that needed for positive results by intravenous injection. Scott (1940) adsorbed gonadotropins on to kaolin at pH 4, and found on elution with sodium hydroxide that most if not all the toxic substances in urine remained adsorbed on the kaolin. This method, too, concentrates the gonadotropins, the concentration depending on the amount of eluent used. To try to obviate these difficulties the following procedure was evolved.
منابع مشابه
P92: Investigation of the Role of Glucocorticoid Receptors on the Anxiety in Mice: A Preliminary Report
Some studies suggested that glucocorticoid receptors activities can modulate fear and anxiety. According to that, the purpose of this research is to assess the modulatory effect of glucocorticoid receptors on the anxiety assessed in plus maze. In this research mice with medium weight of 20-25 g were used. The male and female animals separately sorted in two groups as control and experiment rand...
متن کاملThe Relationship between Modified Biophysical Profile, Standard Biophysical Profile, and Neonatal Outcomes of High-risk Pregnancies
Introduction: High-risk pregnancies can result in many complications for the fetus. In these pregnancies, different tests such as non-stress test (NST), biophysical profile (BPP), oxytocin contraction stress test (OCT), and Doppler sonography can be used to evaluate fetal health. As standard BBP requires more time and expertise, in this study, we evaluated the relationship between standard BPP,...
متن کاملThe Use of the Friedman Test for Pregnancy with Chimpanzees *
Since Friedman's discovery5 in 1929 that urine from pregnant women would induce ovulation when injected into young female rabbits, there have been several attempts to use the test with various other mammals. These are summarized by Snyder and Wislocki8 and by Schultz and Snyder.7 Reports of experimental and clinical observations on the use of the Friedman test for diagnosis of pregnancy are ver...
متن کاملVULVAR CARCINOMA IN PREGNANCY: A CASE REPORT
ABSTRACT Carcinoma of the vulva has commonly been recognized as a disease of postmenopausal women, but some cases have been reported in young women during pregnancy. Medical records were reviewed for a patient with vulvar carcinoma diagnosed in pregnancy. Using Medline and cross references, pertinent articles were sought and reviewed. A 28-year-old Afghan woman in her sixth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of clinical pathology
دوره 4 1 شماره
صفحات -
تاریخ انتشار 1951